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Nembutal sodium pentobarbital powder, unlike other lethal drugs, may not require any additional drugs. Only anti-emetic drugs must be taken in advance, in order to prevent any vomiting from occurring. This has been partially endorsed by experts in administration of the death penalty, whereby a pure barbiturate method has been deemed less painful and more successful than prior 3-drug approaches and newer concoctions involving e.g. Midazolam (in the traditional 3-drug approach, a barbiturate was one of the components). There have, however, been reports of less successful attempts, the cause of which have been debated. The use of pentobarbital-only has also been called into question by some experts on capital punishment. sodium phenobarbital  effects , phenobarbital sodium solubility in ethanol, phenobarbital sodium drugbank, phenobarbital sodium pediatric, phenobarbital sodium structure,

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Potentiating the cocktail and masking the taste
It is usually recommended to drink some alcohol immediately after (not prior) to the Nembutal ingestion to potentiate its effect and mask the very bitter taste.
Eating a big meal prior to or after the drug ingestion is not recommended to reduce chances of slow drug absorption or vomiting. Dignitas offers clients chocolates to deal with the bitter taste of the drug.

 

Time To Death
Experience in the world has notified that after ingesting 20 grams to 50 grams of either nembutal powder or lethal, death generally occurs within few hours and depending of the age and weight of the subject.